Protective Effect of Ixora Coccinea Flowers against Cadmium Chloride induced Nephrotoxicity Model in Rats

The present study was carried out to evaluate the protective effects of the aqueous extract of Ixora coccinea flowers (AICF) against CdCl2 induced renal toxicity in rats. The study was performed using 30 (rats), divided into five groups i.e control group, CdCl2 treated group and plant extract at a dose of 100, 200 and 400 mg/kg body weight along with CdCl2 treated groups. The exposure to CdCl2 exhibit marked destruction in kidney function characterized by decrease in the body weight, increase in kidney weight and increase in serum creatinine, urea and uric acid levels, decrease of total protein levels and histopathological variations. The pretreatment of AICF at a dose of 100, 200 and 400 mg/kg body weight for eight days significantly improved the various biochemical parameters in a dose dependent manner. Furthermore, the histological alterations were also ameliorated by AICF. The AICF showed apparent dose dependent proactive effect on CdCl2 induced nephrotoxicity model in rats.