组蛋白
癌症研究
癌症
染色质
癌变
表观遗传学
组蛋白乙酰转移酶
细胞周期
癌细胞
生物
乙酰化
基因
遗传学
作者
Dimitrios Schizas,Aikaterini Mastoraki,Leon Naar,Diamantis I. Tsilimigras,Ioannis Katsaros,Vasiliki Fragkiadaki,Georgia‐Sofia Karachaliou,Nikolaos Arkadopoulos,Theodore Liakakos,Demetrios Moris
标识
DOI:10.2174/0929867326666190712160842
摘要
Chemotherapy resistance is a rising concern in Gastric Cancer (GC) and has led to the investigation of various cellular compounds. Α functional equilibrium of histone acetylation and deacetylation was discovered in all cells, regulated by Histone Acetyltransferases and Deacetylases (HDACs), controlling chromatin coiling status and changing gene expression appropriately. In accordance with recent research, this equilibrium can be dysregulated in cancer cells aiding in the process of carcinogenesis and tumor progression by altering histone and non-histone proteins affecting gene expression, cell cycle control, differentiation, and apoptosis in various malignancies. In addition, increased HDAC expression in GC cells has been associated with increased stage, tumor invasion, nodal metastases, increased distant metastatic potential, and decreased overall survival. HDAC inhibitors could be used as treatment regimens for GC patients and could develop important synergistic interactions with chemotherapy drugs. The aim of this article is to review the molecular identity and mechanism of action of HDAC inhibitors, as well as highlight their potential utility as anti-cancer agents in GC.
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