The Function and Role of Dipeptidyl Peptidase-4 Inhibitors in the Management of Type 2 Diabetes

In addition, it delays gastric emptying4 and, when infused in pharmacological concentrations, enhances satiation and facilitates weight loss in people with T2DM.5 However, its utility as a therapeutic agent in T2DM has been limited by its extremely short half-lifeThe major form of secreted GLP-1, GLP-1-(7,36)-amide, requires the presence of the two N-terminal amino acids for biological activity.