化学
体外
细胞培养
索拉非尼
A549电池
立体化学
组合化学
癌细胞系
人体乳房
药理学
生物化学
癌症研究
癌症
癌细胞
内科学
生物
肝细胞癌
医学
遗传学
作者
Min Sun,Xiaoqing Wu,Junqing Chen,Jin Cai,Meng Cao,Min Ji
标识
DOI:10.1016/j.ejmech.2010.02.005
摘要
Two series of novel diaryl ureas have been designed and synthesized, with their in vitro antitumor effect screened on human non-small cell lung cancer (NSCLC) cell line A549 and human breast cancer cell line MDA-MB-231. Some target compounds demonstrated significant inhibitory activities against both cell lines. Compared to contrast drug Sorafenib, 1b, 1d, 1f, 1i were found to demonstrate more potent antitumor activities. The structures of all the newly synthesized compounds were determined by 1H, 13C NMR, MS, IR and elementary analysis.
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