Protein Structure Prediction

Abstract The state of the art of the field of protein structure prediction is reviewed. The strengths and weaknesses of the three general approaches, comparative modelling, threading and template‐free modelling, are discussed, and an overview of the results of the critical assessment of structure prediction (CASP) protein structure prediction experiments are summarized. The implications for protein structure prediction of the finding that the library of solved single domain protein structures is likely complete are examined. Recent advances in the modelling of membrane proteins and proteome scale protein structure predictions are presented. Finally, the key remaining unsolved proteins in protein structure prediction are described.