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化学
酶
血红素
辅因子
单加氧酶
生物催化
血红素蛋白
细胞色素P450
反应性(心理学)
生物化学
立体化学
催化作用
基质(水族馆)
酶分析
组合化学
蛋白质工程
酶催化
反应机理
医学
替代医学
病理
摘要
Research at the interface of enzyme chemistry and organic chemistry of metal complexes is particularly rewarding employing metal porphyrins as cofactor surrogates. Three examples are discussed: active site analogues of cytochrome P450 and chloroperoxidase (CPO), both heme-thiolate proteins, and enzyme models of β-carotene monooxygenase, a non-heme iron protein. In all cases, catalytically active synthetic systems could be established displaying chemical reactivity close to the native proteins. Further, it is demonstrated that enzymatic reaction mechanisms can be elucidated by means of active site analogues (CPO) and information can be obtained from enzyme models that is useful to explain certain aspects of Nature's sophisticated approach to develop very efficient catalysts.
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