Antitumor and Other Effects of 24R,25-Dihydroxycholecalciferol in Lewis Lung Carcinoma Causing Abnormal Calcium Metabolism in Tumor-Bearing Mice

Lewis lung carcinoma was found to cause hypercalcemia in tumor-bearing mice. 24R,25(OH)2D3 (K-DR, prepared by Kureha Chemical Ind.) significantly prolonged the survival time of mice with Lewis lung carcinoma. K-DR exhibited an antimetastatic effect on Lewis lung carcinoma, and also had an analgesic effect in mice with Lewis lung carcinoma.