IL-8 –251T/A and IL-12B 1188A/C polymorphisms are associated with gout in a Chinese male population

Objectives: Gout is caused by monosodium urate (MSU) crystal-induced inflammation of the joints and periarticular tissues. MSU crystals activate NALP3 and mediate interleukin (IL)-1β generation from its inactive pro-form, resulting in cellular activation and an IL-8-mediated neutrophil influx into the joint. IL-8 and IL-12 are important chemokines related to the initiation and amplification of acute and chronic inflammatory processes. In this study, we investigated whether the IL-8 –251T/A and IL-12 1188A/C polymorphisms are associated with susceptibility to gout in a Chinese Han male population.