Features of the gut prokaryotic virome of Japanese patients with Crohn’s disease

人病毒体 生物 长尾病毒科 瘤胃球菌 基因组 肠道菌群 蔷薇花 微生物学 微生物群 失调 遗传学 噬菌体 拟杆菌 大肠杆菌 细菌 免疫学 基因
作者
Takayuki Imai,Ryo Inoüe,Atsushi Nishida,Yoshihiro Yokota,So Morishima,Masahiro Kawahara,Hiroyuki Kusada,Hideyuki Tamaki,Akira Andoh
出处
期刊:Journal of Gastroenterology [Springer Science+Business Media]
卷期号:57 (8): 559-570 被引量:14
标识
DOI:10.1007/s00535-022-01882-8
摘要

The gut virome is mainly composed of bacteriophages and influences gut homeostasis and pathogenic conditions. In this study, we analyzed the gut prokaryotic virome in Japanese patients with Crohn's disease (CD).We collected 19 fecal samples from CD patients and 16 samples from healthy controls. The gut bacteriome was analyzed by 16S rRNA gene sequencing and the virome was profiled by shotgun metagenomic sequencing.Despite no differences in richness and evenness, there was a significant difference in the overall structure of the gut virome between CD patients and controls (P = 0.013). CrAssphage and Staphylococcus virus, belonging to the order Caudovirales, were dominant in the gut virome of controls and CD patients. The abundance of crAssphage was significantly greater in CD patients than controls (P = 0.021). Lactococcus, Enterococcus and Lactobacillus phages were present only in CD patients, while Xanthomonas and Escherichia phages were unique to the controls. In the gut bacteriome of CD patients, richness and evenness were significantly lower, and a significant difference in the overall structure was observed between groups (P = 0.014). The gut bacteriome of CD patients was characterized by a decrease of the genera Faecalibacterium, Roseburia, and Ruminococcus and an increase of the family Enterobacteriaceae. There were more significant correlations between viruses and bacteria in CD patients than controls.The gut virome of CD patients was distinct from that of healthy controls in a Japanese population. An altered gut virome may be one of the factors associated with the bacterial dysbiosis of CD.
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