肠细胞
脂质代谢
血脂异常
乳糜微粒
脂滴
生物
脂质积聚
细胞生物学
小肠
脂蛋白
生物化学
疾病
内科学
胆固醇
医学
极低密度脂蛋白
作者
Murooj Ghanem,Gary F. Lewis,Changting Xiao
标识
DOI:10.1016/j.bbalip.2022.159197
摘要
Processing of dietary fats in the intestine is a highly regulated process that influences whole-body energy homeostasis and multiple physiological functions. Dysregulated lipid handling in the intestine leads to dyslipidemia and atherosclerotic cardiovascular disease. In intestinal enterocytes, lipids are incorporated into lipoproteins and cytoplasmic lipid droplets (CLDs). Lipoprotein synthesis and CLD metabolism are inter-connected pathways with multiple points of regulation. This review aims to highlight recent advances in the regulatory mechanisms of lipid processing in the enterocyte, with particular focus on CLDs. In-depth understanding of the regulation of lipid metabolism in the enterocyte may help identify therapeutic targets for the treatment and prevention of metabolic disorders.
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