聚(N-异丙基丙烯酰胺)
光热治疗
淀粉
材料科学
碘
自愈水凝胶
癌症治疗
共聚物
化学工程
高分子化学
聚合物
癌症
纳米技术
化学
医学
复合材料
有机化学
内科学
工程类
冶金
作者
Man Fan,Mengyao Li,Xiao Wang,Yonggui Liao,Hong Wang,Jingyi Rao,Yajiang Yang,Qin Wang
标识
DOI:10.1002/marc.202200203
摘要
Although photothermal therapy (PTT) can effectively eliminate tumors, the normal tissues near tumors are inevitably damaged by heat and infected by bacteria, which greatly limits the therapeutic effect. In this work, an injectable thermosensitive hydrogel based on iodine-loaded starch-g-poly(N-isopropylacrylamide) (PNSI) is developed to overcome this problem. FTIR, 1 H NMR, and UV-vis spectra confirm the graft copolymerization of poly(N-isopropylacrylamide) with starch and the formation of "iodine-starch" complex. Transmission electron microscope images show PNSI polymer self-assembles into regular spherical nanogel with a size of ≈50 nm. The concentrated nanogel dispersion is a sol at room temperature and transforms to hydrogel at body temperature. Under NIR laser irradiation for 10 min, the ΔT of the nanogel dispersion approachs about 20 °C with excellent thermal stability and high cytotoxicity due to the photothermal effect of the "iodine-starch" complex. After intratumor injection, this injectable hydrogel efficiently inhibites the tumor growth under 808 nm laser irradiation. Furthermore, it can also suppress Staphylococcus aureus infection in the wound post-PTT due to the release of iodine, which promotes wound healing. Therefore, this injectable thermosensitive "iodine-starch" composite hydrogel with advantages of good biocompatible and easy preparation possesses potential application for tumor photothermal therapy and antibacterial infection.
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