眶额皮质
灵活性(工程)
神经科学
心理学
任务(项目管理)
功能(生物学)
认知心理学
编码
前额叶皮质
计算机科学
生物
认知
统计
经济
基因
管理
进化生物学
生物化学
数学
作者
Erin L. Rich,Frederic M. Stoll,Peter H. Rudebeck
标识
DOI:10.1016/j.conb.2017.11.002
摘要
Humans and animals demonstrate extraordinary flexibility in choice behavior, particularly when deciding based on subjective preferences. We evaluate options on different scales, deliberate, and often change our minds. Little is known about the neural mechanisms that underlie these dynamic aspects of decision-making, although neural activity in orbitofrontal cortex (OFC) likely plays a central role. Recent evidence from studies in macaques shows that attention modulates value responses in OFC, and that ensembles of OFC neurons dynamically signal different options during choices. When contexts change, these ensembles flexibly remap to encode the new task. Determining how these dynamic patterns emerge and relate to choices will inform models of decision-making and OFC function.
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