内科学
医学
胰岛素抵抗
内分泌学
代谢综合征
肥胖
血压
血糖性
胰岛素
糖尿病
人口
脂蛋白
胆固醇
环境卫生
作者
Kristin K. Hoddy,Christopher L. Axelrod,Jacob T. Mey,Adithya Hari,Robbie A. Beyl,Jourdan B Blair,Wagner Silva Dantas,John P. Kirwan
出处
期刊:Obesity
[Wiley]
日期:2021-11-24
卷期号:30 (1): 39-44
被引量:14
摘要
Abstract Objective Metabolically healthy obesity (MHO) is often defined as the absence of metabolic syndrome in the presence of obesity. However, phenotypic features of MHO are unclear. Insulin sensitivity in MHO was cross‐sectionally compared with metabolically unhealthy obesity (MUO) and a reference group of young healthy participants without obesity. Methods Sedentary adults ( n = 96) undergoing anthropometric, blood chemistries, maximal aerobic capacity, and euglycemic‐hyperinsulinemic clamp measurements were classified by BMI (<25 and ≥30 kg/m 2 ). MUO was defined as having obesity with metabolic syndrome (≥2 additional risk factors). Data were analyzed using a linear mixed models approach. Results Body weight was similar between MHO and MUO. Body fat (percentage) and high‐density lipoprotein cholesterol were higher ( p < 0.001), and systolic blood pressure, triglycerides, glucose, and insulin were lower in MHO versus MUO ( p < 0.03, all). The MHO group also had lower high‐density lipoprotein cholesterol and higher low‐density lipoprotein cholesterol, diastolic blood pressure, and insulin compared with the reference. Both the MHO and MUO groups displayed impaired insulin sensitivity compared with the reference control ( p < 0.001). Conclusions Participants with MHO had distinct clinical measures related to hypertension, lipid metabolism, and glycemic control compared with a healthy reference group. Peripheral insulin resistance in obesity independent of metabolic status portends increased risk for type 2 diabetes in the MHO patient population.
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