西妥因1
肝损伤
内科学
炎症
酒精性肝病
锡尔图因
医学
内分泌学
髓样
免疫学
下调和上调
生物
肝硬化
NAD+激酶
生物化学
酶
基因
作者
Ruixue Ren,Yong He,Dong Ding,Aoyuan Cui,Huarui Bao,Jing Ma,Xin Hou,Yu Li,Dechun Feng,Xiaoling Li,Suthat Liangpunsakul,Bin Gao,Hua Wang
出处
期刊:Hepatology
[Lippincott Williams & Wilkins]
日期:2021-09-12
卷期号:75 (3): 646-660
被引量:73
摘要
Aging increases the susceptibility of alcohol-induced liver injury in mice and humans through the down-regulation of the neutrophilic SIRT1-C/EBPα-miR-223 axis, which could be a therapeutic target for the prevention and/or treatment of ALD.
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