纳米团簇
体内
端粒酶
核酸
体外
聚集诱导发射
临床前影像学
生物物理学
DNA
端粒
荧光
化学
纳米技术
材料科学
生物
生物化学
遗传学
光学
基因
物理
作者
Xiang Ran,Zhenzhen Wang,Fang Pu,Enguo Ju,Jinsong Ren,Xiaogang Qu
出处
期刊:Materials horizons
[The Royal Society of Chemistry]
日期:2021-01-01
卷期号:8 (6): 1769-1775
被引量:36
摘要
Visual monitoring of telomerase activity in living cancer cells and in vivo is essential for clinical diagnosis and treatment. However, most detection methods were performed in vitro due to the difficulty of probes entering cells and the interferences from complex biological environments. Herein, we developed a novel probe based on Au nanoclusters (AuNCs) with a nucleic acid-driven aggregation-induced emission (AIE) property for the first time. The probe was applied for detection of telomerase with high sensitivity. Importantly, the probe could achieve telomerase imaging in living cells and in solid tumor tissue in vivo. The study provided a specific connection fashion of metal nanoclusters for AIE generation. It holds great potential for the development of AIE-active metal nanoclusters as a diagnostic tool for disease detection in vitro as well as in vivo.
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