运输机
一元羧酸盐转运体
流出
肌酸
生物合成
膜
肝细胞
化学
生物化学
血液供应
细胞生物学
内科学
内分泌学
生物
医学
基因
外科
体外
作者
Ryuta Jomura,Yu Tanno,Shin‐ichi Akanuma,Yoshiyuki Kubo,Masanori Tachikawa,Ken‐ichi Hosoya
出处
期刊:American Journal of Physiology-gastrointestinal and Liver Physiology
[American Physiological Society]
日期:2021-08-01
卷期号:321 (2): G113-G122
被引量:10
标识
DOI:10.1152/ajpgi.00143.2021
摘要
Our study is the first to identify the role of monocarboxylate transporter 12 (MCT12) as a transporter of creatine (Cr) in the liver. MCT12 was found to significantly contribute to the efflux of Cr on the sinusoidal membrane of the hepatocytes. Since hepatocytes are known to be involved in creatine biosynthesis. The present findings can be beneficial for the regulation of Cr biosynthesis and supply.
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