孕烷
类固醇
多重耐药
糖苷
立体化学
化学
P-糖蛋白
糖基化
药理学
生物
生物化学
激素
抗生素
作者
Xiu‐Qing Song,Lin-Lin Tian,Tao Ye,Hu Liu,Hua Zhang
出处
期刊:Fitoterapia
[Elsevier]
日期:2023-07-01
卷期号:168: 105551-105551
被引量:1
标识
DOI:10.1016/j.fitote.2023.105551
摘要
Twenty compounds comprising four pregnane steroids (2–4 & 20) and 16 pregnane glycosides (1 & 5–19) have been obtained from the ethanol extract of the roots of a Dai ethnological herb, Marsdenia tenacissima. Their structures were characterized on the basis of comprehensive spectroscopic analyses with 17 ones (1–17) being reported for the first time, including the rare cases (2 & 3) of free C21 steroids with 17α-acetyl substitution, compounds 4–7 bearing an unusual 14α-OH, and the first examples with simultaneous 14α-OH/17α-acetyl substitution (7) and glycosylation at C-12 position (10 & 11). An empirical rule for the identification of C-17 configuration, in C21 steroids incorporating the marsdenin constitution structure, was also proposed. All the isolates, along with an array of previously reported analogues in our compound library, were screened for their chemo-reversal ability against P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) in MCF-7/ADR cell line, and six compounds exhibited moderate MDR reversal activity with reversal folds ranging from 1.92 to 4.44.
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