Nickel‐Catalyzed Suzuki‐Miyaura Cross‐Coupling Reaction of Aliphatic Alcohol Derivatives

Reactions leveraging readily available starting materials are valuable for synthetic utility, especially for late‐stage functionalization. Herein, we report a nickel‐catalyzed Suzuki‐Miyaura cross‐coupling reaction of aliphatic sulfonates with aryl boronic acids. This reaction provides straightforward access to an array of arylated products in good yield. We have established a one‐pot protocol allowing for the arylation of alcohols in a single reaction vessel. Additionally, an asymmetric reaction was developed to provide enantioenriched α‐aryl and heteroaryl glutarimides in good yield and enantioselectivity.