Nickel‐Catalyzed Suzuki–Miyaura Cross‐Coupling Reaction of Aliphatic Alcohol Derivatives

Reactions leveraging readily available starting materials are valuable for synthetic utility, especially for late-stage functionalization. Herein, we report a nickel-catalyzed Suzuki-Miyaura cross-coupling (XC) reaction of aliphatic sulfonates with aryl boronic acids. This reaction provides straightforward access to an array of arylated products in good yield. We have established a one-pot protocol allowing for the arylation of alcohols in a single reaction vessel. Additionally, an asymmetric reaction was developed to provide enantioenriched α-aryl and heteroaryl glutarimides in good yield and enantioselectivity.