医学
有氧运动
内科学
阻力训练
2型糖尿病
2型糖尿病
随机对照试验
脑源性神经营养因子
糖尿病
神经营养素
萧条(经济学)
物理疗法
内分泌学
神经营养因子
受体
宏观经济学
经济
作者
Adel Donyaei,Elina Kiani,Hassan Bahrololoum,Othmar Moser
摘要
In this study, we assessed the effects of a 12-week combined aerobic-resistance training and subsequent detraining on Beck Depression Inventory (BDI) score and mediating role of BDNF and also investigated whether exercise-induced alterations are maintained following a short period of detraining in women with type 2 diabetes (T2D).Thirty-four women with T2D were randomly assigned to experimental or control group (age: 60.6 ± 6.3, body mass index (BMI): 30.2 ± 1.3 kg/m2 , HbA1c: 8.09 ± 0.73%). The exercise training comprised of combined aerobic-resistance programme (50%-70% heart rate reserve for aerobic exercise, and 50%-70% 1 repetition maximum for resistance exercise, respectively) performed three sessions per week over 12 weeks. The intervention period was followed by an 8-week detraining period. Data were collected at baseline and also following exercise intervention and detraining. Data were analysed by linear mixed model at p < 0.05.After 12 weeks of combined exercise training and 8 weeks of detraining, there was a significant difference in BDNF (0.08; 95% confidence interval [CI] = 0.07-0.10; p = 0.001), fasting blood glucose (FBG) (-45.41; CI = -50.83, -39.98; p = 0.001), insulin (-6.47; CI = -7.04, -5.9; p = 0.001), HOMA-IR (-3.76; CI = -4.07, -3.45; p = 0.001) and BDI score (-17.17; CI = -20.29, -14.05; p = 0.001) between the experimental and control group. Multiple mediation analysis indicated that BDNF seems to have a mediating role in exercise-induced improvement of depression (p = 0.04). After the detraining period, BDI score remained unchanged and it showed a significant increase compared to before the start of training (p = 0.001).It may be concluded that exercise training improves depression that is likely to be explained by increased BDNF concentration in TD2. In spite of decreased BDNF concentration following an 8-week detraining, depression score was maintained.
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