球形
材料科学
溶解
粒径
结晶
化学工程
粒子(生态学)
热稳定性
头孢呋辛
复合材料
化学
生物化学
海洋学
地质学
工程类
抗生素
作者
Jingjing Cai,Xueyou Qin,Jiahui Li,Yanbo Liu,Hui Yan,Shuo Wang,Mingyang Chen,Weiguo Hu,Songgu Wu,Junbo Gong
标识
DOI:10.1016/j.powtec.2023.119257
摘要
Cefuroxime Sodium (CS) is a low-toxicity and highly effective antibiotic drug with a wide application market. Its polymorph form β has the advantage of thermal stability and resistance to degradation. However, poor powder properties cause filtration difficulties, severe electrostatic phenomena and difficulties in automated dispensing, which limit its application. In order to improve the powder properties and stability of CS from the source, we used a one-step crystallization method to prepare CS (form β) with high sphericity and uniform particle size. The spherulites of form β of CS (β spherulites) have excellent powder properties, with high flowability (32.8°), good sphericity (90.2%), low C.V. (45.6%), and adjustable particle size distribution. Thanks to improved powder properties, the β spherulites exhibits 40% higher thermal stability and maximum 41% faster dissolution rate in the compatible solutions, compared to commercially available products, which implies the β spherulites is more competitive in powder formulations.
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