Alkaloid-metabolites from the mangrove-derived fungus Penicillium robsamsonii HNNU0006

Nine metabolites, including three undescribed alkaloids pyripyropenes VW (1–2), penicioxa A (4), two previously reported pyripyropene A (3), oxaline (5), three grisephenone-type xanthone derivatives (6–8), and a diphenyl ether derivative 4-chloro-7,4′-dihydroxy-5,2′-dimethoxy-2-methylformate-6′-methybenzophone (9), were isolated from cultures of the mangrove-derived fungus Penicillium robsamsonii HNNU0006. Their structures were determined by spectroscopic analysis, ECD calculations, together with DP4+ probability analysis. Furthermore, all the isolated compounds were tested for cytotoxicity and anti-phytopathogenic fungal activities. Compounds 6–8 showed moderate cytotoxicity against tumor cell lines A549, with IC50 values ranging from 5.68 ± 0.21 to 9.71 ± 0.34 μg/mL, respectively.