上皮-间质转换
细胞周期
癌症
生物
癌基因
分子医学
细胞
间充质干细胞
癌症研究
细胞生物学
转移
遗传学
作者
Guoan Zhang,Sen Hou,Shuyue Li,Yequan Wang,Wen Cui
标识
DOI:10.3892/ijo.2024.5636
摘要
Since its discovery, the role of the transcription factor, signal transducer and activator of transcription 3 (STAT3), in both normal physiology and the pathology of numerous diseases, including cancer, has been extensively studied. STAT3 is aberrantly activated in different types of cancer, fulfilling a critical role in cancer progression. The biological process, epithelial‑mesenchymal transition (EMT), is indispensable for embryonic morphogenesis. During the development of cancer, EMT is hijacked to confer motility, tumor cell stemness, drug resistance and adaptation to changes in the microenvironment. The aim of the present review was to outline recent advances in knowledge of the role of STAT3 in EMT, which may contribute to the understanding of the function of STAT3 in EMT in various types of cancer. Delineating the underlying mechanisms associated with the STAT3‑EMT signaling axis may generate novel diagnostic and therapeutic options for cancer treatment.
科研通智能强力驱动
Strongly Powered by AbleSci AI