Clinical observation of cyclosporine eye drops with artificial tears for dry eyes

AIM:To explore the therapeutic effect of cyclosporine eye drops combined with artificial tears for dry eyes. METHODS:One hundred and two patients(204 eyes)with dry eye as the research objects were collected from January 2015 to November 2015 and randomly divided into 3 groups:control group, subgroup A, subgroup B, 34 patients(68 eyes)in each group. The control group did not do special treatment. Subgroup A was treated with artificial tears eye drops 3 times per day and subgroup B with cyclosporine eye drop first, 15min later with artificial tears, 3 times per day. All patients were treated for 8wk. Tear ferning test(TFT), corneal fluorescein staining(FL), Schirmer I test(SIt), breakup time of tear film(BUT)and conjunctive impression cytology(CIC)in each group were observed and compared. RESULTS:(1)At 4wk after treatment, fern fractional crystallization grade of subgroup B was better than those of subgroup A and control group(χ2=16.345,P=0.003); at 8wk after treatment, fern fractional crystallization grade of subgroup B was better than those of subgroup A and control group(P<0.05).(2)The FL of control group at 8wk was worse compared with before treatment(t=-4.500,P=0.003); the FL of subgroup A and subgroup B became lighter and the scores decreased compared with before treatment(P<0.05); at 4 and 8wk after treatment, the FL scores of subgroup B were lower than those of subgroup A(t=3.553, P=0.006; t=4.523, P=0.001).(3)Compared with control group, the BUT of subgroup B at 4 and 8wk prolonged(P<0.05); the BUT of subgroup B had no difference with subgroup A(P>0.05).(4)At 8wk after treatment, conjunctival impression cytology of subgroup B was better than those of the control group and subgroup A(P<0.05).(5)At 4wk after treatment, SIt of subgroup B increased, compared with subgroup A and the control group(χ2=6.384, P=0.012); at 8wk after treatment, SIt of subgroup A and B were better than those before the treatment, SIt of the B subgroup was better than that of subgroup A(all P<0.05). CONCLUSION:Cyclosporin eye drops combined with artificial tears can improve micro environment of the tear, increase the amount of tear secretion, extend BUT and enhance the stability of the tear film.