声动力疗法
聚乙烯亚胺
伤口愈合
金黄色葡萄球菌
光动力疗法
体内
光敏剂
吲哚青绿
硒
材料科学
化学
药理学
微生物学
细菌
医学
免疫学
外科
生物
生物化学
光化学
生物技术
转染
冶金
有机化学
基因
遗传学
作者
Wenjing Huang,Binbin Hu,Yalin Yuan,Huaqiang Fang,Jie Jiang,Qun Li,Yi Zhuo,Xuetao Yang,Jinlu Wei,Xiaolei Wang
出处
期刊:ACS Biomaterials Science & Engineering
[American Chemical Society]
日期:2023-02-24
卷期号:9 (3): 1341-1351
被引量:5
标识
DOI:10.1021/acsbiomaterials.2c01119
摘要
In this paper, we synthesized selenium nanoparticles (SeNPs) that could be effectively excited by pure yellow light (YL) source to enhance antibacterial ability. Meanwhile, YL could also play the role of anti-inflammatory and promote wound healing. In addition, in order to overcome the problem of low penetration depth of photodynamic therapy (PDT), SeNPs were encapsulated with polyethylenimine (PEI), then modified with the sound sensitive agent indocyanine green (ICG), realizing the combined photoacoustic therapy to promote the healing of wounds infected by drug-resistant bacteria. The antibacterial efficiency of methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli (E. coli) reached more than 99% in in vitro and in vivo experiments within 10 min, which could safely and quickly kill drug-resistant bacteria to repair and heal wounds.
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