一氧化氮
癌症研究
纳米医学
材料科学
转移
激进的
纳米技术
肿瘤微环境
谷胱甘肽
生物物理学
肿瘤细胞
药理学
化学
生物化学
医学
纳米颗粒
生物
有机化学
内科学
癌症
酶
作者
Debao Ren,Yang Cheng,Wenxuan Xu,Wenjun Qin,Tonghui Hao,Fei Wang,Yun Hu,Lixin Ma,Cheng Zhang
出处
期刊:Small
[Wiley]
日期:2022-11-24
卷期号:19 (4)
被引量:5
标识
DOI:10.1002/smll.202205772
摘要
The interaction between platelets and circulating tumor cells (CTCs) contributes to distal tumor metastasis by protecting CTCs from immunological assault and shear stress, which can be disrupted by nitric oxide (NO) through inhibiting platelet-mediated adhesion. To eradicate primitive tumors and inhibit CTC-based pulmonary metastasis, a novel biomimetic nanomedicine (mCuMNO) is designed by encapsulating Cu+ -responsive S-nitrosoglutathione as a NO donor into a copper-based metal-organic framework (CuM). This work discovers that mCuMNO can target tumor regions and deplete local glutathione (GSH) to reduce Cu2+ to Cu+ , followed by triggering NO release and hydroxyl radicals (·OH) production, thereby interrupting platelet/CTC interplay and contributing to chemodynamic therapy. Detailed studies demonstrate that mCuMNO exhibits high efficiency and safety in tumor therapy and antimetastasis activity, sheding new light on the development of CuM-based tumor synthetic therapy.
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