癌症生物标志物
前列腺癌
生物标志物
癌症
疾病
医学
癌症检测
结直肠癌
乳腺癌
肺癌
肿瘤科
内科学
生物
生物化学
作者
Mugip Rahaman Abdul Wahab,Thirunavukkarasu Palaniyandi,Maddaly Ravi,Sandhiya Viswanathan,Gomathy Baskar,Hemapreethi Surendarn,Sidhu P. Gangadharan,Barani Kumar Rajendran
标识
DOI:10.1016/j.prp.2023.154812
摘要
Cancers continue to be of major concern due to their serious global socioeconomic impact, apart from the continued increase in the incidence of various cancer types. A major challenge that this disease poses is due to the low "early detection" rates which limit the therapeutic outcomes for the affected individuals. Current research has highlighted the discovering biomarkers that help in early cancer detection and the development of technologies for the detection and quantification of such biomarkers. Biomarkers range from proteins to nucleic acids, and can be specific to a particular cancer type. Detection and quantification of such biomarkers at low levels from biological samples is being made possible by the advent of developing biosensors and by using biomedical engineering technologies such as tumor-on-a-chip models. Here, we present biomarkers that can be helpful for the early detection of breast, colorectal, esophageal, lung, liver, ovarian, and prostate cancer. In addition, we discuss the potential of circulating tumor cell DNA (ctDNA) as an early diagnostic marker. Finally, biosensors available for the detection of cancer biomarkers, which is a recent advancement in this area of research, are discussed.
科研通智能强力驱动
Strongly Powered by AbleSci AI