Objective To evaluate the clinic outcome and complication of non-variceal upper gastrointestinal bleeding using endoscopic hemostasis. Methods 126 non-variceal upper gastrointestinal bleeding patients were selected as treatment group using endoscopic hemostasis,56 synchronization patients were selected as control group using conservative treatment,and the clinical outcome and complication were evaluated. Results Endoscopic hemostasis showed more significant advantages in treating non-variceal upper gastrointestinal bleeding than conservative treatment,without different rates of complication. Conclusion Endoscopic hemostasis possesses the advantages including safety,convenience,miniinjury and greatly reducing the emergency surgery operation rate.