A comparative study of Aripiprazole and Ziprasidone in the treatment of schizophrenia

Objective:To compare efficacy and safety of Aripiprazole and Ziprasidone in the treatment of schizophrenia.Methods:60 patients with schizophrenia were randomly into two groups,treated with Aripiprazole or Ziprasidone for 8 weeks.The Positive and Negative Symptom Scale(PANSS) and Treatment Emergent Symptom Scale(TESS) were used to evaluate efficacy and adverse effect respectively.Results:There was no significent difference between the Aripiprazole group and the Ziprasidone group after eight weeks(P0.05).Incidence of adverse effects in the Aripiprazole group was lower than that in the Ziprasidone group,but the difference was not significant(P0.05).The rates of extrapyramidal symptoms in the Aripiprazole group were significantly higher than those in the Ziprasidonegroup.The rates of nausea,vomit,headache,dizzy,drowsiness in the Ziprasidone group were significantly higher than those in the Aripiprazole group.But these side effects were not serious,and patients often had good tolerance for them.Conclusion:Effect of Aripiprazole and Ziprasidone in the treatment of schizophrenia is basically the same,but the side effects of the drug are significantly different.