A STUDY ON THE GENETIC GRANSMISSION BETWEEN THE PARENTS WITH HBsAg AND THEIR CHILDREN.

Objective:To study genetic transmission from the parents with HBsAg to their children.Methods:Five serum HBV markers(HBsAg,anti HBs,HBeAg,anti HBe and anti HBc) and serum free HBV DNA were detected in 234 individuals from 117 families.Rusults:There was a significant difference in total infection rate of HBV,HBsAg,HBeAg,HBV DNA between the children of males with HBsAg and those of males with no HBsAg.The positive rate of HBV serum markers combination of father and their children was 52 4% in 63 families that father and children were all infected with HBsAg.HBV DNA mainly distributed in the combination that father and their children were all with HBsAg,there was a significant difference between that and other combinations.HBV DNA rised in accord with HBeAg.The childrens HBeAg and HBV DNA were all positive,who born after occurrence of HBeAg.HBV DNA of father with high titer HBeAg rised in accordence with there childrens.Conclusion:It showed that hepatitis B virus,can be transmitted by inheritance between the fathers and their children.