Simultaneous tumor-photothermal therapy and bone-tissue regeneration by a bifunctional 3D-pringting bioceramic scaffold

Event Abstract Back to Event Simultaneous tumor-photothermal therapy and bone-tissue regeneration by a bifunctional 3D-pringting bioceramic scaffold Chengtie Wu1 and Jiang Chang1 1 Shanghai Institute of Ceramics, Chinese Academy of Sciences, State Key Laboratory of High Performance Ceramics and Superfine Microstructure, China Malignant bone tumor is one of the major bone diseases. The treatment of such a bone disease typically requires the removal of bone tumor and regeneration of tumor-initiated bone defects simultaneously. To address this issue, it is required that implanted biomaterials should combine the bifunctions of both therapy and regeneration. In this work, a bifunctional graphene oxide (GO)-modified β-tricalcium phosphate (GO-TCP) composite scaffold combining high photothermal effect with significantly improved bone-forming ability was prepared by 3D-printing and surface-modification strategies. The prepared GO-TCP scaffolds exhibited excellent photothermal effects under the irradiation of 808nm near infrared laser (NIR) even at an ultra-low power density of 0.36W/cm2, while no photothermal effects were observed for pure β-TCP scaffolds. The photothermal temperature of GO-TCP scaffolds could be effectively modulated in the range of 40~90°C by controlling the used GO concentrations, surface-modification times and power densities of NIR. The distinct photothermal effect of GO-TCP scaffolds induced more than 90% of cell death for osteosarcoma cells (MG-63) in vitro, and further effectively inhibited tumor growth in mouse. Meanwhile, the prepared GO-TCP scaffolds possessed the improved capability to stimulate the osteogenic differentiation of rabbit bone mesenchymal stem cells (rBMSCs) by upregulating bone-related gene expression, and significantly promoted new bone formation in the bone defects of rabbits as compared to pure β-TCP scaffolds. These results successfully demonstrated that the prepared GO-TCP scaffolds have bifunctional properties of photothermal therapy and bone regeneration, which is believed to pave the way to design and fabricate novel implanting biomaterials in combination of therapy and regeneration functions. the National High Technology Research and Development Program of China (863 Program, SS2015AA020302) Keywords: Bone Regeneration, Tissue Engineering, 3D scaffold Conference: 10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016. Presentation Type: New Frontier Oral Topic: Ceramics Citation: Wu C and Chang J (2016). Simultaneous tumor-photothermal therapy and bone-tissue regeneration by a bifunctional 3D-pringting bioceramic scaffold. Front. Bioeng. Biotechnol. Conference Abstract: 10th World Biomaterials Congress. doi: 10.3389/conf.FBIOE.2016.01.01258 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Mar 2016; Published Online: 30 Mar 2016. Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Chengtie Wu Jiang Chang Google Chengtie Wu Jiang Chang Google Scholar Chengtie Wu Jiang Chang PubMed Chengtie Wu Jiang Chang Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.