Influence of Shanwei Prescription on P16 Protein in Atrophic Gastritis Patients in Precancer period with Deficiency of Both Qi and Yin

Objective To observe the curative effect in patients with chronic atrophic gastritis CAG with deficiency of both Qi and Yin and observe the expression of antioncogene protein P16 integral score before and after treatment. Methods The selected patients were suffered from chronic atrophic gastritis CAG with gastric mucous membrane dysplasia Dys and/or intestinal metaplasia IM diagnosed by endoscopy and pathologic examination. Sixty patients were randomly divided into treatment group and control group. The patients of treatment group were administrated with Shanwei invigorating the construction and function of stomach prescription and the patients of control group with heriacium tablet for six months. Result The overall effective rate of treatment group and control group was 90.00% and 55.67% respectively. There was an obvious difference between the treatment group and control group P0.01. In the treatment group some obvious improvements in the atrophy extent intestinal metaplasia and atypical hyperplasia were observed P0.05. The antioncogene protein P16 expression of treatment group was obviously higher than that of control group P0.05. Conclusion The Shanwei prescription has definite curative effect on chronic atrophic gastritis CAG with deficiency of both Qi and Yin and may reverse the pathologic change of the gastric mucous membrane on a certain extent by increasing the expression level of P16 protein probably.