Objective To investigate the significance and method for early fundus examination in infants.Methods Retinal imagine system( RetCamⅢ) was applied to a screening of the fundus diseases in 2 697 infants,and an analysis of the screening result was conducted. Results One hundred and forty-two infants with retinopathy of prematurity( ROP) were confirmed,including two complicated with fundus of dbinoism and macular coloboma. Fifty-six cases of fundus abnormalities were found in the full-term infants. Conclusion Fundus examination for infants aged 3years and younger can help to confirm eye diseases in early stage in children. RetCam Ⅲ is an important means of fundus examination in infants.