Partitioning and concentration of egg lysozyme between the serum and paranasal tissue after administration of egg lysozyme.

Partitioning of egg-white lysozyme between the serum and paranasal tissue was investigated using the ELISA method.1) Egg-white lysozyme was detected in the paranasal tissues of 7 of 8 subjects given exogenous lysozyme reached a peak concentration in the serum in 60 minutes, whereas, 90 minutes was required to reach peak concentrations in the paranasal tissues.2) Antibodies against egg-white lysozyme were detected in the serum of 4 of 5 subjects given exogenous lysozyme.3) Differences in serum concentrations of lysozyme between subjects given exogenous lysozyme and subjects non-receiving lysozyme were not significant.However, lysozyme concentrations in the paranasal tissues of all subjects receiving exogenous lysozyme were higher than in subjects not receiving an exogenous source of the enzyme.