Death regulation beyond Apoptosis:: Necroptosis

Death events encoutered by cells have been always classified into two well-defined molecular pathways. Necrosis, unregulated and passive process being the result of an accidental injury compromising the cell whilst apoptosis is a controlled, and coordinated method profited by the organism as a clearance to remove senescent cells. Apoptosis and necrosis have been deeply studied due to the close relation leading to cancer development when misfunctions occur in their mechanisms. Recenty some cells have been showing a different pattern of cell death, sharing features with both known mechanisms. A new paradigm in cell death has the potencial to revolutionise cell therapy offering a new insight to how the organism regulate its own fate: Necroptosis.