Diffuse Optical Tomography for Noninvasive Functional Brain Imaging in Awake Behaving Humans

We present a high density diffuse optical tomography (wHD-DOT) system capable of mapping hemodynamics in awake behaving humans. The key to this system is an array of fiber-free light source/detector pairs covering the frontal head, obtaining optical data for three-dimensional (3-D) DOT image reconstruction. Both phantom and in vivo human subject experiments were conducted to validate the wHD-DOT system.