Long-term impact of transmural healing on the clinical outcome of pediatric Crohn's disease

Background and aims: Transmural healing (TH) is emerging as a new therapeutic goal in Crohn's disease (CD). Biologic therapy induces clinical remission, mucosal healing (MH) and, in a lower rate of patients, also TH in pediatric CD. The aim of this study is to evaluate the impact of TH on the clinical course of pediatric CD after 24 and 36 months of biologic therapy.