ATP-triggered drug release system based on ZIF-90 loaded porous poly(lactic-co-glycolic acid) microspheres

Poly(lactic-co-glycolic acid) (PLGA) based microparticles have been widely applied in drug delivery system, but pristine PLGA particles suffers from low efficiency in release and non-targeted effect for drug delivery system. Inspired by cancer cells environment, we have fabricated an ATP-triggered delivery system based on porous PLGA microspheres covering drug-loaded ZIF-90. The system contains controlled doxorubicin releasing because ZIF-90 nanocrystals are easily collapsed under exposing to high-concentration ATP environment. In addition, [email protected] microparticles also perform low toxicity and 2.37 % hemolysis, and improved fluorescence intensity of doxorubicin by loading riboflavin sodium phosphate benefited from their partial Förster resonance energy transfer. This novel ATP-triggered drug delivery system based on porous PLGA particles could be widely utilized to design effective drug release biomaterials for gastric and lung cancer.