废止
化学
催化作用
铑
组合化学
功能群
反应条件
药物化学
立体化学
有机化学
聚合物
作者
Huan Li,Yanshuo Han,Zijiao Yang,Zheng Yao,Lianhui Wang,Xiuling Cui
标识
DOI:10.1016/j.cclet.2020.12.027
摘要
Rhodium(III)-catalyzed [4 + 1] cyclization of azobenzenes with α-Cl ketones has been developed. 3-Acyl-2H-indazoles could be easily afforded in up to 97% yields for more than 30 examples. The obtained products are potentially valuable in organic synthesis and drug discovery. This protocol featured with high efficiency, extensive functional group tolerance and mild reaction conditions. The one-step efficient construction of an anti-inflammatory agent confirms the practicability of this procedure.
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