医学
慢性阻塞性肺病
肺活量测定
随机对照试验
内科学
氧气疗法
统计显著性
肺康复
麻醉
心脏病学
物理疗法
哮喘
作者
Michele Vitacca,Mara Paneroni,Elisabetta Zampogna,Antonio Spanevello,Piero Ceriana,Annalisa Carlucci,Paolo Banfi,Gabriele Pappacoda,Ludovico Trianni,Antonio Brogneri,Stefano Belli,Elena Paracchini,Maria Aliani,Vito Spinelli,Francesco Gigliotti,Barbara Lanini,Marta Lazzeri,Enrico Clini,Nicolino Ambrosino
出处
期刊:European Respiratory Journal
日期:2019-09-28
被引量:1
标识
DOI:10.1183/13993003.congress-2019.rct449
摘要
We compared in COPD with CRF undergoing training, HFOT (AIRVO2® Fisher&Paykel, (Flow/Temperature ranged 20-60 l/min/30-37°C respectively) vs oxygen Venturi Mask (V-mask) at iso-FiO2 on improving exercise tolerance. 171 patients were allocated to two groups; all used the same high-intensity exercise program (1 session/day for ≥ 20 sessions) with different oxygen device. BMI, spirometry and co morbidities have been collected. Baseline and after training exercise tolerance (Constant Work Rate Exercise Test, CWERT + 6-min walk test, 6MWT), respiratory (MIP/MEP) and biceps/quadriceps muscle strength, blood gases, Barthel Index and Barthel Dyspnoea Index, CAT and MRF-26 were measured. Patients’ satisfaction has been evaluated. 71 and 66 patients were analysed for HFOT and V-mask respectively being 15% and 24% the rate of drop-out. All variables improved after training in both groups with similar satisfaction. Comparing the two groups, only meters at 6MWT resulted statistically higher in HFOT group (p=0.029). HFOT group performed 153 seconds more than V-mask at CWERT, without statistical significance (p=0.057). Improvers (gain > 150 sec at CWERT) were 44% and 56% for V-mask and HFOT, respectively. FEV1% prd higher than 30% (OR 2.44, p=0.025) and higher baseline endurance time (OR 1.15, p=0.024) predicted improvers. Low BMI (OR 0.9298, p=0.038) predicted drop-outs. CWERT improvement was positively related to comorbidities (p=0.025) and CAT (p=0.031), while negatively to PaO2/FiO2 (p=0.04). We have confirmed the strong indication to training program in advanced COPD with CRF; HFOT used during training may further increase exercise tolerance.
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