心脏毒性
PI3K/AKT/mTOR通路
蛋白激酶B
细胞毒性T细胞
化学
自噬
药理学
芹菜素
细胞凋亡
医学
生物化学
抗氧化剂
类黄酮
毒性
体外
有机化学
作者
Fatemeh Yarmohammadi,A. Wallace Hayes,Gholamreza Karimi
摘要
Abstract Cardiotoxicity is a critical concern in the use of several cytotoxic drugs. Induction of apoptosis, inflammation, and autophagy following dysregulation of the PI3K/Akt signaling pathway contributes to the cardiac damage induced by these drugs. Several natural compounds (NCs), including ferulic acid, gingerol, salvianolic acid B, paeonol, apigenin, calycosin, rutin, neferine, higenamine, vincristine, micheliolide, astragaloside IV, and astragalus polysaccharide, have been reported to suppress cytotoxic drug‐induced cardiac injury. This article reviews these NCs that have been reported to have a protective effect against cytotoxic drug‐induced cardiotoxicity through regulation of the PI3K/Akt signaling pathway.
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