穿心莲内酯
细胞毒性
化学
甲酰化
立体化学
癌细胞系
细胞培养
化学合成
癌细胞
酮
羟基化
组合化学
生物化学
癌症
体外
有机化学
内科学
酶
催化作用
生物
医学
遗传学
作者
Rada Bunthawong,Uthaiwan Sirion,Arthit Chairoungdua,Kanoknetr Suksen,Pawinee Piyachaturawat,Apichart Suksamrarn,Rungnapha Saeeng
标识
DOI:10.1016/j.bmcl.2020.127741
摘要
Two new series of 19-silylether- and 19-formyl-7-acetyl-12-amino-14-deoxyandrographolide analogues were designed and synthesized from natural andrographolide via key step reactions including allylic hydroxylation, tandem CAE reaction and one pot formylation. Evaluation of their cytotoxicity against eight cancer cells line found 6e exhibited the highest activity on MCF-7 cancer cell (IC50 2.93) and comparable to the drug elipticin. Replacement of silylether at C-19 with formyl group exhibited selective activity on P-388 cell line. Computational studies revealed the amino group at C-12 and O-acetoxy at C-7 position play significant roles in cytotoxicity against MCF-7 cancer cells. Cytotoxicity of these two series highlights the importance of 12-substituted-14-deoxyandrographolide scaffold and these types of compounds could be employed in future developments against breast cancer.
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