自闭症谱系障碍
自闭症
智力残疾
心理学
人口
氢化可的松
联想(心理学)
相关性
内科学
临床心理学
医学
精神科
几何学
数学
环境卫生
心理治疗师
作者
Toshio Ohtsubo,Yoshito Mizoguchi,Chie Aita,Yoshiomi Imamura,Momoko Kobayashi,Yutaka Kunitake,Hiroshi Tateishi,Takefumi Ueno,Akira Monji
标识
DOI:10.1038/s41598-024-57459-3
摘要
Stereotypies are one of the diagnostic criteria for autism spectrum disorder (ASD) and are common to both ASD and intellectual disability (ID). Previous studies have been inconclusive, with some showing a positive correlation between stereotypies and cortisol, while others have shown a negative correlation. We hypothesised and investigated the presence of ASD as one of the variables involved in this discrepancy. We tested the following hypotheses on serum cortisol in a total of 84 hospitalised patients with severe ID and ASD with severe ID. Hypothesis (1) Higher levels of stereotypies are associated with higher levels of serum cortisol. Hypothesis (2) The presence of ASD will moderate the association between stereotypies and high serum cortisol levels. The results of the analysis supported hypotheses (1) and (2). We also found that in the population with ID, serum cortisol levels were significantly lower in the ASD group compared to the non-ASD group. The present findings that the association between stereotypies and serum cortisol levels in people with severe ID is moderated by the presence of ASD suggest that the stress response system may function differently in people with ID and ASD than in the general population.
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