自噬
舞蹈
细胞内
生物
先天免疫系统
细胞生物学
战斗或逃跑反应
细胞
免疫
微生物学
免疫系统
免疫学
遗传学
基因
细胞凋亡
艺术
文学类
作者
Milton Osmar Aguilera,Laura Ruth Delgui,Fulvio Reggiori,Patricia Silvia Romano,María Isabel Colombo
标识
DOI:10.1002/1873-3468.14788
摘要
Intracellular infections as well as changes in the cell nutritional environment are main events that trigger cellular stress responses. One crucial cell response to stress conditions is autophagy. During the last 30 years, several scenarios involving autophagy induction or inhibition over the course of an intracellular invasion by pathogens have been uncovered. In this review, we will present how this knowledge was gained by studying different microorganisms. We intend to discuss how the cell, via autophagy, tries to repel these attacks with the objective of destroying the intruder, but also how some pathogens have developed strategies to subvert this. These two fates can be compared with a Tango, a dance originated in Buenos Aires, Argentina, in which the partner dancers are in close connection. One of them is the leader, embracing and involving the partner, but the follower may respond escaping from the leader. This joint dance is indeed highly synchronized and controlled, perfectly reflecting the interaction between autophagy and microorganism.
科研通智能强力驱动
Strongly Powered by AbleSci AI