Dose tapering of dupilumab in patients with persistently controlled atopic dermatitis: a Spanish multicenter cohort study

International Journal of DermatologyVolume 63, Issue 3 p. 402-404 Letter to the Editor Dose tapering of dupilumab in patients with persistently controlled atopic dermatitis: a Spanish multicenter cohort study Miguel A. Lasheras-Pérez, Corresponding Author Miguel A. Lasheras-Pérez [email protected] orcid.org/0000-0001-7429-9592 Department of Dermatology, La Fe University and Polytechnic Hospital, Valencia, SpainSearch for more papers by this authorRodolfo D. Palacios-Diaz, Rodolfo D. Palacios-Diaz orcid.org/0000-0002-8353-7481 Department of Dermatology, La Fe University and Polytechnic Hospital, Valencia, SpainSearch for more papers by this authorVíctor A. González-Delgado, Víctor A. González-Delgado orcid.org/0000-0002-0330-7599 Department of Dermatology, Valencia University Clinical Hospital, Valencia, SpainSearch for more papers by this authorLorena V. Cobreros, Lorena V. Cobreros Department of Dermatology, University Hospital Arnau de Vilanova, Valencia, SpainSearch for more papers by this authorGabriel O. Pereira-Resquin Galván, Gabriel O. Pereira-Resquin Galván Department of Dermatology, University Hospital Arnau de Vilanova, Valencia, SpainSearch for more papers by this authorJavier Miquel-Miquel, Javier Miquel-Miquel Department of Dermatology, University Hospital Arnau de Vilanova, Valencia, SpainSearch for more papers by this authorCarolina Labrandero Hoyos, Carolina Labrandero Hoyos orcid.org/0000-0002-3270-7428 Department of Dermatology, Valencia General Hospital, Valencia, SpainSearch for more papers by this authorVioleta Zaragoza Ninet, Violeta Zaragoza Ninet Department of Dermatology, Valencia General Hospital, Valencia, SpainSearch for more papers by this authorFrancisco J. Melgosa Ramos, Francisco J. Melgosa Ramos Department of Dermatology, Hospital Doctor Peset, Valencia, SpainSearch for more papers by this authorJosé M. Sánchez-Motilla, José M. Sánchez-Motilla Department of Dermatology, Hospital Doctor Peset, Valencia, SpainSearch for more papers by this authorFernando Navarro-Blanco, Fernando Navarro-Blanco Department of Dermatology, La Fe University and Polytechnic Hospital, Valencia, SpainSearch for more papers by this authorDaniel Martín-Torregrosa, Daniel Martín-Torregrosa orcid.org/0009-0008-7918-4733 Department of Dermatology, La Fe University and Polytechnic Hospital, Valencia, SpainSearch for more papers by this authorRafael Botella-Estrada, Rafael Botella-Estrada Department of Dermatology, La Fe University and Polytechnic Hospital, Valencia, SpainSearch for more papers by this authorMercedes Rodríguez-Serna, Mercedes Rodríguez-Serna Department of Dermatology, La Fe University and Polytechnic Hospital, Valencia, SpainSearch for more papers by this author Miguel A. Lasheras-Pérez, Corresponding Author Miguel A. Lasheras-Pérez [email protected] orcid.org/0000-0001-7429-9592 Department of Dermatology, La Fe University and Polytechnic Hospital, Valencia, SpainSearch for more papers by this authorRodolfo D. Palacios-Diaz, Rodolfo D. Palacios-Diaz orcid.org/0000-0002-8353-7481 Department of Dermatology, La Fe University and Polytechnic Hospital, Valencia, SpainSearch for more papers by this authorVíctor A. González-Delgado, Víctor A. González-Delgado orcid.org/0000-0002-0330-7599 Department of Dermatology, Valencia University Clinical Hospital, Valencia, SpainSearch for more papers by this authorLorena V. Cobreros, Lorena V. Cobreros Department of Dermatology, University Hospital Arnau de Vilanova, Valencia, SpainSearch for more papers by this authorGabriel O. Pereira-Resquin Galván, Gabriel O. Pereira-Resquin Galván Department of Dermatology, University Hospital Arnau de Vilanova, Valencia, SpainSearch for more papers by this authorJavier Miquel-Miquel, Javier Miquel-Miquel Department of Dermatology, University Hospital Arnau de Vilanova, Valencia, SpainSearch for more papers by this authorCarolina Labrandero Hoyos, Carolina Labrandero Hoyos orcid.org/0000-0002-3270-7428 Department of Dermatology, Valencia General Hospital, Valencia, SpainSearch for more papers by this authorVioleta Zaragoza Ninet, Violeta Zaragoza Ninet Department of Dermatology, Valencia General Hospital, Valencia, SpainSearch for more papers by this authorFrancisco J. Melgosa Ramos, Francisco J. Melgosa Ramos Department of Dermatology, Hospital Doctor Peset, Valencia, SpainSearch for more papers by this authorJosé M. Sánchez-Motilla, José M. Sánchez-Motilla Department of Dermatology, Hospital Doctor Peset, Valencia, SpainSearch for more papers by this authorFernando Navarro-Blanco, Fernando Navarro-Blanco Department of Dermatology, La Fe University and Polytechnic Hospital, Valencia, SpainSearch for more papers by this authorDaniel Martín-Torregrosa, Daniel Martín-Torregrosa orcid.org/0009-0008-7918-4733 Department of Dermatology, La Fe University and Polytechnic Hospital, Valencia, SpainSearch for more papers by this authorRafael Botella-Estrada, Rafael Botella-Estrada Department of Dermatology, La Fe University and Polytechnic Hospital, Valencia, SpainSearch for more papers by this authorMercedes Rodríguez-Serna, Mercedes Rodríguez-Serna Department of Dermatology, La Fe University and Polytechnic Hospital, Valencia, SpainSearch for more papers by this author First published: 16 January 2024 https://doi.org/10.1111/ijd.17030 Conflict of interest: None. Funding source: None. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Open Research Data availability statement The data presented in this study are available on request from the corresponding author. References 1Ardern-Jones MR, Buchanan EE, Njungu S, O'Driscoll D. Successful dose reduction of dupilumab in atopic dermatitis. Br J Dermatol. 2023; 188(5): 678–679. https://pubmed.ncbi.nlm.nih.gov/36662536/ 10.1093/bjd/ljad011 PubMedWeb of Science®Google Scholar 2Worm M, Simpson EL, Thaçi D, Bissonnette R, Lacour JP, Beissert S, et al. Efficacy and safety of multiple dupilumab dose regimens after initial successful treatment in patients with atopic dermatitis: a randomized clinical trial. JAMA Dermatol. 2020; 156(2): 131–143. https://jamanetwork.com/journals/jamadermatology/fullarticle/2757721 10.1001/jamadermatol.2019.3617 PubMedWeb of Science®Google Scholar 3Spekhorst LS, Boesjes CM, Loman L, Zuithoff NPA, Bakker DS, Kamphuis E, et al. Successful tapering of dupilumab in patients with atopic dermatitis with low disease activity: a large pragmatic daily practice study from the BioDay registry. Br J Dermatol. 2023; 189(3): 327–335. https://pubmed.ncbi.nlm.nih.gov/37177895/ 10.1093/bjd/ljad159 PubMedWeb of Science®Google Scholar 4Mastorino L, Gelato F, Richiardi I, Cavaliere G, Quaglino P, Ortoncelli M, et al. Dose reduction of dupilumab in atopic patients with controlled atopic dermatitis: a safe and effective practice? J Eur Acad Dermatol Venereol. 2023; 37: e691–e692. https://onlinelibrary.wiley.com/doi/full/, https://doi.org/10.1111/jdv.18908 10.1111/jdv.18908 CASPubMedWeb of Science®Google Scholar 5Spekhorst LS, Bakker D, Drylewicz J, Rispens T, Loeff F, Boesjes CM, et al. Patient-centered dupilumab dosing regimen leads to successful dose reduction in persistently controlled atopic dermatitis. Allergy. 2022; 77(11): 3398–3407. https://pubmed.ncbi.nlm.nih.gov/35837880/ 10.1111/all.15439 CASPubMedWeb of Science®Google Scholar Volume63, Issue3March 2024Pages 402-404 ReferencesRelatedInformation