光热治疗
过氧化氢
硫化氢
介孔二氧化硅
纳米颗粒
化学
光热效应
谷胱甘肽
分子
癌症治疗
介孔有机硅
吸附
纳米技术
介孔材料
催化作用
生物物理学
材料科学
癌症
有机化学
硫黄
医学
酶
内科学
生物
作者
Xiaofeng Liang,Mekhrdod Subhoni,Ying Zou,Kai Luo,Shuhong Fang,Pengcheng Xia,Shufang Ning,Litu Zhang,Chen Wang
出处
期刊:Pharmaceutics
[MDPI AG]
日期:2023-10-10
卷期号:15 (10): 2443-2443
被引量:1
标识
DOI:10.3390/pharmaceutics15102443
摘要
Traditional treatment methods for tumors are inefficient and have severe side effects. At present, new therapeutic methods such as phototherapy, chemodynamic therapy, and gasodynamic therapy have been innovatively developed. High concentrations of hydrogen sulfide (H2S) gas exhibit cancer-suppressive effects. Herein, a Prussian blue-loaded tetra-sulfide modified dendritic mesoporous organosilica (PB@DMOS) was rationally constructed with glutathione (GSH)-triggered/photothermal-enhanced H2S signaling molecule release properties for gas therapy. The as-synthesized nanoplatform confined PB nanoparticles in the mesoporous structure of organosilica silica due to electrostatic adsorption. In the case of a GSH overexpressed tumor microenvironment, H2S gas was controllably released. And the temperature increases due to the photothermal effects of PB nanoparticles, further enhancing H2S release. At the same time, PB nanoparticles with excellent hydrogen peroxide catalytic performance also amplified the efficiency of tumor therapy. Thus, a collective nanoplatform with gas therapy/photothermal therapy/catalytic therapy functionalities shows potential promise in terms of efficient tumor therapy.
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