偏头痛
前额叶腹内侧皮质
冲动性
腹侧纹状体
前额叶皮质
医学
纹状体
发作性
慢性偏头痛
静息状态功能磁共振成像
奖励制度
神经科学
心理学
认知
精神科
物理医学与康复
多巴胺
癫痫
内科学
作者
David M. Niddam,Shih-Wei Wu,Kuan-Lin Lai,Yun-Yen Yang,Yen Feng Wang,Shuu Jiun Wang
出处
期刊:Cephalalgia
[SAGE]
日期:2023-03-01
卷期号:43 (4): 033310242311580-033310242311580
标识
DOI:10.1177/03331024231158088
摘要
Medication overuse headache shares several characteristics with substance use disorders. However, key features of substance use disorders such as increased impulsivity and alterations in reward processing remain little explored in medication overuse headache.Temporal discounting and impulsive decision making behavior and the associated brain mechanisms were assessed in 26 chronic migraine patients with medication overuse headache and in 28 healthy controls. Regions-of-interest analyses were first performed for task-related regions, namely the ventral striatum and the ventromedial and dorsomedial prefrontal cortices. Resting-state functional connectivity between these regions were then explored. An additional 27 chronic migraine patients without medication overuse headache were included for comparison in the latter analysis.Patients with medication overuse headache showed steeper temporal discounting behavior than healthy controls. They also showed weaker subjective value representations in the dorsomedial prefrontal cortex, when accepting larger delayed rewards, and in ventral striatum and ventromedial prefrontal cortex, when accepting the smaller immediate reward. Resting-state functional connectivity was reduced among the valuation regions when comparing patients with medication overuse headache to the other two control groups.Patients with medication overuse headache were characterized by altered processing and dysconnectivity in the reward system during intertemporal choices and in the resting-state.
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