化学
药效团
抗真菌
比基内利反应
嘧啶
药品
组合化学
药理学
有机化学
立体化学
催化作用
生物
微生物学
作者
Syed Faizan,Tamsheel Fatima Roohi,Ruby Mariam Raju,Yuvaraj Sambandam,B. R. Prashantha Kumar
标识
DOI:10.1016/j.molstruc.2023.136020
摘要
One of the largest classes of organic molecules are dihydropyrimidines and its derivatives. They are widely used in a variety of pharmacological and industrial applications. Their biological and pharmacological activities include antihypertensive, antidiabetic, anti-inflammatory, antibacterial, antifungal, anticancer, and antiviral activities. The presence of pyrimidine and pyrimidine-containing rings in the substructures of therapeutically effective drugs has drawn considerable interest amongst the scientific fraternity. The potential therapeutic use of these heterocycles has prompted medicinal chemists to synthesize drugs that contain these heterocycles. Against this backdrop, this review examines the one-pot multicomponent reaction, that is, the Biginelli reaction and its mechanism. Also, we reviewed various synthetic approaches for the synthesis of dihydropyrimidines and their diverse pharmacological activities reported in the last two decades. We highlight different marketed drugs with dihydropyrimidine as a pharmacophore as well as patented dihydropyrimidines in the recent past.
科研通智能强力驱动
Strongly Powered by AbleSci AI