医学
类风湿性关节炎
关节炎
炎性关节炎
荟萃分析
银屑病性关节炎
内科学
置信区间
祖细胞
生物标志物
免疫学
子群分析
肿瘤科
干细胞
生物化学
化学
生物
遗传学
作者
Hui Zhao,Lanlan Fang,Yuting Chen,Yubo Ma,Quan Zhou,Shengqian Xu,Zongwen Shuai,Guoqi Cai,Faming Pan
出处
期刊:Journal of Investigative Medicine
[BMJ]
日期:2023-06-29
卷期号:71 (8): 929-940
标识
DOI:10.1177/10815589231182320
摘要
The objective of this meta-analysis was to systematically review existing evidence and evaluate variations in levels of circulating endothelial progenitor cells (EPCs) among individuals with psoriatic arthritis (PsA), juvenile idiopathic arthritis (JIA), and rheumatoid arthritis (RA). Relevant studies were identified through database searches, and 20 records were enrolled. We used the fixed-effect model or random-effect model to estimate the pooled standardized mean difference (SMD) with 95% confidence intervals (CIs) in circulating EPC levels between inflammatory arthritis patients and controls. The results showed that circulating EPC levels differed among subtypes of inflammatory arthritis, with significantly lower levels in patients with RA (SMD = -0.848, 95% CI = -1.474 to -0.221, p = 0.008) and PsA (SMD = -0.791, 95% CI = -1.136 to -0.446, p < 0.001). However, no statistically significant difference was found in circulating EPC levels between patients with JIA and controls (SMD = -1.160, 95% CI = -2.578 to 0.259, p = 0.109). Subgroup analyses suggested that in patients with RA, circulating EPC levels were influenced by age, disease activity, and duration. Although many studies have investigated circulating EPC levels in patients with inflammatory arthritis, the results have been inconsistent. This meta-analysis offers a comprehensive overview of the existing evidence and emphasizes the association between levels of circulating EPCs and various types of arthritis. However, further research is needed to determine the specific mechanisms underlying the observed differences in EPC levels in different types of arthritis and to establish the clinical utility of this biomarker.
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