化学
磷腈
分子内力
催化作用
酰胺
分子间力
功能群
组合化学
催化循环
基础(拓扑)
基质(水族馆)
有机化学
分子
数学分析
聚合物
海洋学
数学
地质学
作者
Junpei Matsuoka,Yumika Fujimoto,Akari Miyawaki,Yasutomo Yamamoto
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-12-19
卷期号:24 (51): 9447-9451
被引量:1
标识
DOI:10.1021/acs.orglett.2c03870
摘要
A method for the synthesis of cyclic amides via phosphazene base-catalyzed intramolecular hydroamidation of amide alkenes was developed. The reaction using a catalytic amount of P4-base had a good functional group tolerance and a broad substrate scope and could also be used to synthesize lactam, cyclic urea, and oxazolidinone compounds. This catalytic system was expanded to a one-pot intramolecular hydroamidation and intermolecular hydroalkylation. Deuterium labeling and radical trapping experiments provided mechanistic insights into the catalytic cycle of the hydroamidation reaction.
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