Spermidine Treatment Attenuates Systemic and Gut Oxidative Stress, Neuropathology and Cognitive Deficits in D‐galactose Induced Aging Rats

Our findings suggest that spermidine exerts the beneficial effects on cognition through reducing systemic/brain oxidative stress in D-galactose-induced aging rats. Therefore, it is possible that spermidine should be considered as a novel therapeutic option for ameliorating neuropathology in aging condition.